Fig. 4: Administered MSCs in the Is exerted anti-inflammatory and anti-liver fibrosis effect.
From: The distinct roles of mesenchymal stem cells in the initial and progressive stage of hepatocarcinoma
a Rats were fed with DEN water for 8 weeks and liver sections were stained with H&E (bar: 50 μm). b The expressions of TNF-α, IL-1β, IL-6, and IFN-γ mRNAs were semiquantified by real-time PCR. c Serum level of the cytokines was detected by the Luminex technology (Bio-Plex, Bio-Rad). d Sirius red staining and immunostaining for α-SMA in the rat livers of DEN and DEN + MSC (Is) group at 8th week. Quantification is shown in the graph (right). Scale bar: 100 μm. Values are shown as mean ± SEM (*P < 0.05, **P < 0.01, ***P < 0.001). Representative of three independent experiments
