Fig. 5: Cf effect on TNFR1-induced necroptosis in cIAP-depleted cells.
From: Proteasome inhibition blocks necroptosis by attenuating death complex aggregation
a Time course of membrane permeability in HT-29 cells either NT or pretreated with S followed by treatment with T/S/V (S- > T/S/V) or T/S/V/Cf (S- > T/S/V/Cf) (upper panel) or with T/CH/V (S- > T/CH/V) or T/CH/V/Cf (S- > T/CH/V/Cf) (lower panel), depicted as a percentage of T/CH (24 hpt) control. b Time course of cell membrane permeability of HT-29-shcIAP1 (upper panel) and HT-29-shcIAP2 (lower panel) following treatment with T/S/V or T/S/V/Cf. c IB of cIAP1, cIAP2, RIPK1, RIPK3, and pMLKL in Sol. and Pellet cell fractions of HT-29 cells, HT-29-shcIAP1, and HT-29-shcIAP2 cells following 6 hpt with T/S, T/S/V, or T/S/V/Cf, as indicated
