Fig. 8: Exposure to PQ increases dopaminergic neuron degeneration in astrocytic JWA-deficient mice. | Cell Death & Disease

Fig. 8: Exposure to PQ increases dopaminergic neuron degeneration in astrocytic JWA-deficient mice.

From: Astrocytic JWA deletion exacerbates dopaminergic neurodegeneration by decreasing glutamate transporters in mice

Fig. 8

a, b JWA WT and JWA CKO mice were trained 3 days on the rotarod until their motor performance was assessed. Behavioral assays of climbing time in pole test, the time taken for mice to descend a pole (T-TLA). The time spent on the rod was calculated (in seconds) (n = 15). c, d Levels of DA and DOPAC were analyzed by HPLC coupled to electrochemical detection in striatum tissues (n = 7–8). e Immunohistochemical staining and quantitative data for TH-positive neurons in the SNc (n = 4). Scale bar = 200 µm. f Immunohistochemical staining and quantitative data for GFAP-positive neurons in the SNc (n = 4). Scale bars = 200 μm (low magnification) and 50 μm (high magnification). Data are presented as mean ± SEM, one-way ANOVA, *P < 0.05, **P < 0.01. g A schematic diagram illustrates astrocytic JWA deficiency aggravates dopaminergic neuron death induced by environmental toxins

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