Fig. 3: Sunitinib-mediated NF-κB activation depends on IRE1α/TRAF2/IKKβ branch of ER stress.

Wild type (WT) 786-O cells and their knockout counterparts were treated with 10 μM of sunitinib (Sun) for 3 h. Cytoplasmic and nuclear extracts were subjected to western blot analysis using specific antibodies