Table 4 Univariate and multivariate analysis of disease-free survival in CRC patients

From: Nuclear receptor binding protein 1 correlates with better prognosis and induces caspase-dependent intrinsic apoptosis through the JNK signalling pathway in colorectal cancer

Variables

Univariate analysis

Multivariate analysis

 

HR (95% CI)

P

HR (95% CI)

P

Gender

  Female

1

0.103

  

  Male

1.333 (0.944, 1.882)

   

Age

  ≤60

1

0.711

  

  >60

1.068 (0.755, 1.509)

   

Location

  Colon

1

0.194

  

  Rectum

1.279 (0.883, 1.843)

   

Differentiation

  Well/moderate

1

<0.001

1

<0.001

  Poorly

3.434 (2.387, 4.941)

 

2.515 (1.727, 3.662)

 

Histological type

  Adenocarcinoma

1

0.925

  

  Mucous carcinoma

1.026 (0.599, 1.758)

   

Preoperative CEA level (ng/mL)

  ≤5

1

0.454

  

  >5

1.140 (0.809, 1.608)

   

pT (invasion depth)

  T1 + T2

1

0.018

  

  T3 + T4

1.918 (1.120,3.286)

   

pN (lymph node metastasis)

  N0

1

<0.001

  

  N1–2

2.043 (1.446, 2.885)

   

pM (distant metastasis)

  M0

1

<0.001

1

<0.001

  M1

11.605 (7.718, 17.450)

6.859 (4.377, 10.748)

  

TNM stage

  I + II

1

<0.001

1

0.004

  III + IV

3.482 (2.413, 5.023)

 

1.856 (1.219, 2.826)

 

NRBP1 expression

  High

1

0.003

1

0.043

  Low

1.686 (1.192, 2.285)

 

1.437 (1.011, 2.041)

 
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