Table 2 Important poteins involved in MAMsPlease confirm caption of Table 2.ok

Name	Localization	Function	Main interactors in MAMs	References
IP3R	ER	Ca²⁺ transport	GRP75, S1R	¹⁵⁵
GRP75	Cytosol	Ca²⁺ transport	VDAC, IP3R	¹⁰⁹
VDAC	Mitochondria	Ca²⁺ transport	GRP75	¹⁰⁹
S1R	ER	Ca²⁺ transport, ER stress	IP3R, BiP	⁶¹
CISD2	ER/mitochondria	Ca²⁺ transport	CISD2, GIMAP5	¹²⁸
GIMAP5	Cytosol	Ca²⁺ transport	CISD2	¹⁴⁴
WFS1	ER	Ca²⁺ transport, ER stress	SERCA	^{9, 10, 156}
SERCA2B	ER	Ca²⁺ transport	WFS1	¹⁴⁹
VAPB	ER	ER/mitochondria tethering	PTPIP51	⁸⁹
PTPIP51	Mitochondria	ER/mitochondria tethering	VAPB	⁸⁹
FIS1	Mitochondria	ER/mitochondria tethering	BAP31	⁹³
BAP31	ER	ER/mitochondria tethering	FIS1, Calnexin	⁹³
PACS2	Cytosol	ER/mitochondria tethering	BAP31	¹⁵⁷
MITOL	Cytosol	ER/mitochondria tethering	MFN2	⁸⁸
MFN2	ER/mitochondria	ER/mitochondria tethering, mitochondrial morphology	MFN1/MFN2	^{83,84,85,86,87}
MFN1	Mitochondria	ER/mitochondria tethering, mitochondrial morphology	MFN2	^{83,84,85,86,87}
S1T	ER	ER/mitochondria tethering	?	⁹⁶
PDZD8	ER	ER/mitochondria tethering	?	⁹⁹
TpM	ER	ER/mitochondria tethering	?	¹⁰⁰
FATE1	Mitochondria	ER/mitochondria tethering	Mitofin, Emerin	⁹⁷
Mitofilin	Mitochondria	ER/mitochondria tethering	FATE1	⁹⁷
Emerin	ER	ER/mitochondria tethering	FATE1	⁹⁷
PML	Cytosol	Apoptosis	?	¹⁵⁸
PERK	ER	ER stress, ER/mitochondria tethering	?	^{66, 159}
Calnexin	ER	ER stress	SERCA2b	^{130, 160}
BiP	ER	ER stress	IP3R, S1R	⁶¹
α-synuclein	ER	ER stress	?	^{121, 161}
HTT	ER	ER stress	?	^{162, 163}
PS1-2	ER	APP processing	APP	¹¹⁶
APOE4	ER	Lipid synthesis	?	¹²⁰

Summary of the most important structural and functional roles of important MAM-resident proteins mentioned in this review along with the corresponding references

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