Fig. 4: Bax loss rescues RbKO neurons.
From: Rb is required for retinal angiogenesis and lamination
a Retinal sections of indicated ages and genotypes were stained for nuclei (DAPI, blue) and division (Ki67, green). b Quantification of data in a. c Sections were stained for nuclei (DAPI, blue) and apoptosis (Casp3, red). d Quantification of data in c. e Sections were stained for nuclei (DAPI, blue), ganglion cells (Brn3, red), rod bipolar cells (PKCα, green), or rod photoreceptors (Rho, green). f, g Quantification of the data in e. White and yellow arrowheads in a, c, e highlight the OPL and OMPL, respectively. Data in b, d, f, g are mean ± SD. Asterisks indicate significant difference between WT and other genotypes, or between RbKO and Rb/Bax DKO as indicated by square brackets (*p < 0.05, **p < 0.01, one-way ANOVA followed by Bonferroni correction). ONL outer nuclear layer, INL inner nuclear layer, GCL ganglion cell layer, OPL outer plexiform layer, OMPL outer misplaced plexiform layer. Scale bar is 50 µm
