Fig. 6: RA inhibits breast cancer bone metastasis and osteolysis in vivo.

MDA-MB-231 cells were injected directly into the tibiae plateau. After 28 days of treatment, representative micro-CT and three-dimensional reconstructed images (a), quantitative data from micro-CT, including BV/TV, trabecular number (Tb.N), and trabecular separation (Tb.Sp) of each group (b) were acquired (n = 6 per group). Sections of tibiae were stained with H&E (c) and TUNEL (d). Magnifications: ×100 (c), and (a, c); and ×200 (b, d) (**p < 0.01)