Fig. 1: Impaired liver regeneration in HDAC3△ mice following 70% PH. | Cell Death & Disease

Fig. 1: Impaired liver regeneration in HDAC3△ mice following 70% PH.

From: Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway

Fig. 1

a The liver weight/body weight ratio was calculated at different time points after PH, and liver reconstitution was notably delayed in the HDAC3△ livers. b The serum AST and ALT levels after PH. c–f Immunohistochemistry for BrdU, Ki67, and p-Histone H3 (Ser10) shows that the proliferation rates are reduced in the HDAC3△ mice after PH (scale bar: 50 μm). g Western blot analysis of cell cycle proteins at different times after PH shows that mitotic hepatocytes are delayed at the G1 phase entrance in the HDAC3△ mice. The levels of the indicated proteins are expressed relative to GAPDH. All data represent the mean ± SD; n = 3–8; *p < 0.05; **p < 0.01; ***p < 0.001

Back to article page