Fig. 1: PFKFB3 overexpressed in liver cancer cells and correlated with poor prognosis in HCC patients.
From: PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT
a Kaplan–Meier analysis for overall survival (OS) of patients based on the data of TCGA. The OS of the PFKFB3 high expression group was worse than that of the PFKFB3 low expression group (p = 0.004). b Western blot analysis of PFKFB3 protein expression in liver cancer cell lines and normal hepatocyte cell line (L02). The PFKFB3 expressed higher in liver cancer cell lines. c Western blot analysis of PFKFB3 protein expression in paired human hepatocellular carcinoma (HCC) and peritumor tissue (T = Tumor tissue, P = Peritumor tissue). The PFKFB3 protein expressed higher in tumor tissues. d qRT-PCR expression analysis of PFKFB3 mRNA in paired human HCC and peritumor tissue (n = 12). The PFKFB3 mRNA expressed higher in tumor tissues. e Immunohistochemistry (IHC) staining of paired human HCC and peritumor tissue. PFKFB3 protein expressed higher in tumor tissues and located mainly in nucleus in human liver cancer tissue. f Kaplan–Meier analysis for OS based on the data of our center. The OS (p = 0.027) of the high expression group were worse than that of the PFKFB3 low expression group. g Kaplan–Meier analysis for disease-free survival (DFS) based on the data of our center. The DFS (p = 0.004) of the high expression group were worse than that of the PFKFB3 low expression group. **p < 0.01
