Fig. 1: Kir6.1 deletion aggravated dopaminergic neuron loss and microglia overactivation in MPTP Parkinson’s disease model mice.
From: Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson’s disease
a Microphotographs of Tyrosine hydroxylase (TH)-positive neurons in the substantia nigra compacta (SNc). b Stereological counts of TH-positive neurons in the SNc. c Microphotographs of ionized calcium-binding adaptor molecule 1 (IBA-1)-positive cells in the SNc. d Stereological counts of IBA-1-positive cells in the SNc. Data are presented as mean ± SEM, **p < 0.01, ***p < 0.001 versus corresponding control (saline) group; #p < 0.05, ##p < 0.01 versus MPTP-treated Kir6.1+/+ groups. n = 6 for each group. MPTP 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
