Fig. 5: Overexpression of GADD45α overcomes radioresistance in cervical cancer cells in vivo.
From: GADD45α sensitizes cervical cancer cells to radiotherapy via increasing cytoplasmic APE1 level
a GADD45α expression levels were examined using immunohistochemistry in a HeLa-XR xenograft model (n = 5 per group). b Combination of GADD45α overexpression and radiation treatment more significantly inhibited tumor growth compared to control or single treatment (n = 5 per group). Tumor volume was measured using MRI. c Combination of GADD45α overexpression and radiation treatment more significantly inhibited cell proliferation compared to control or single treatment in vivo. Immunohistochemistry of the cell proliferation marker Ki-67 (n = 5 per group). d Combination of GADD45α overexpression and radiation treatment more significantly induced cell apoptosis compared to control or single treatment in vivo (n = 5 per group). Apoptotic cells were measured using the TUNEL assay. **p < 0.01; ***p < 0.001
