Fig. 1: PIWIL2 interacts with HDAC3. | Cell Death & Disease

Fig. 1: PIWIL2 interacts with HDAC3.

From: PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation

Fig. 1

a PIWIL2 can only interact with HDAC3 among class I HDACs. b Endogenous interaction between PIWIL2 and HDAC3. c PIWIL2 binds to HDAC3 in a TNT® Quick Coupled Transcription/Translation System. d Co-localization of PIWIL2 and HDAC3 using immunofluorescence assays. e Schematics of PIWIL2 deletion mutants and HDAC3 deletion mutants. f PIWI domain is necessary for PIWIL2 binding with HDAC3. The “ *” indicates a non-specific bind. g C-terminal region of HDAC3 is necessary for HDAC3 binding with PIWIL2

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