Fig. 7: Model of PIWIL2 on proliferation of cancer cell via HDAC3. | Cell Death & Disease

Fig. 7: Model of PIWIL2 on proliferation of cancer cell via HDAC3.

From: PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation

Fig. 7

a In WT cancer cells (at least Hela and HepG2), PIWIL2 stabilizes HDAC3 by inhibiting Siah2-mediated degradation. PIWIL2 binding enhances CK2-mediated phosphorylation of HDAC3. As a result, the expression of p53 is reduced followed by a decrease of p21. b In PIWIL2 knockdown cells, p53 has a relative high expression level and p21 as well

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