Fig. 7: MiR-302d-3p promotes HUVEC proliferation, migration, and cell-cycle progression.
From: c-Jun-mediated microRNA-302d-3p induces RPE dedifferentiation by targeting p21Waf1/Cip1
a, b Proliferation was promoted in ARPE-19 cells transfected with miR-302d-3p mimic compared to NC mimic (a), and was inhibited in cells transfected with miR-302d-3p inhibitor compared to NC inhibitor (b). c, d Migration was suppressed in ARPE-19 cells transfected with miR-302d-3p mimic compared to NC mimic (c), and was promoted in cells transfected with miR-302d-3p inhibitor compared to NC inhibitor (d). e, f Proliferative rates was downregulated in ARPE-19 cells transfected with AcFlag-CDKN1A compared to empty vector (e), and was upregulated in cells transfected with CDKN1A-siRNA compared to scramble siRNA (f). g, h Migration was suppressed in ARPE-19 cells transfected with AcFlag-CDKN1A compared to empty vector (g), and was promoted in cells transfected with CDKN1A-siRNA compared to scramble siRNA (h). i, j No detectable change in apoptosis was revealed in ARPE-19 cells transfected with miR-302d-3p mimic compared to NC mimic (i), nor in cells transfected with miR-302d-3p inhibitor compared to NC inhibitor (j). *p < 0.05; **p < 0.01; ***p < 0.001
