Fig. 1: miR-181a promotes angiogenesis in vitro. | Cell Death & Disease

Fig. 1: miR-181a promotes angiogenesis in vitro.

From: MicroRNA-181a promotes angiogenesis in colorectal cancer by targeting SRCIN1 to promote the SRC/VEGF signaling pathway

Fig. 1

a Increased miR-181a expression is associated with a worse 5-year survival in colorectal adenocarcinoma patients. b miR-181a is upregulated in tumor tissues compared with adjacent non-tumorous tissues (n = 14). c Quantitative RT-PCR analysis of miR-181a expression levels in HT29 cells transfected with control mimic, miR-181a mimic, control inhibitor, or miR-181a inhibitor. d, e Overexpression of miR-181a in HT29 cells promoted tube formation in HUVECs. HUVECs were cultured in the presence of 75% TCM from HT29 cells transfected with control mimic, miR-181a mimic, control inhibitor, or miR-181a inhibitor, scale bars: 100 μm; d representative images of tube formation; eHUVEC branch number. Data are shown as the mean ± SD of three replicates.*P < 0.05; **P < 0.01; ***P < 0.001

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