Fig. 6: Schematic of the importance of neuronal AEG-1 preservation in the nigrostriatal DA system.
From: Upregulation of neuronal astrocyte elevated gene-1 protects nigral dopaminergic neurons in vivo
Following neurotoxic events in the nigrostriatal DA system, AEG-1 transduction in DA neurons prevents the apoptotic cell death of the DA neurons (but not their functional properties). Meanwhile, decreases in the levels of neuronal AEG-1 and the consequent loss of DA neurons were observed. Moreover, AEG-1 transduction in DA neurons can intensify the neurorestorative effects by synergizing with the administration of therapeutic agents for axonal regeneration and the inhibition of abnormal activation of the autophagy–lysosomal pathway. Thus, these results suggest the importance of AEG-1 preservation in potential therapeutic strategies against PD
