Fig. 2: PGC1α has no effect on CCA cell proliferation and tumorigenesis. | Cell Death & Disease

Fig. 2: PGC1α has no effect on CCA cell proliferation and tumorigenesis.

From: PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect

Fig. 2

a Growth curves for the indicated CCA cells evaluated by the CCK-8 assays. b Representative images of the colony formation assays and analysis results. c Cell apoptosis determined by Annexin V/PI staining. d Representative images of the cell cycle analysis and analysis results of indicated CCA cells. e a Representative images of SA-β-gal staining in the indicated cells. Scale bars: 100 μm. b The quantification of positively SA-β-gal staining cells. f Tumor growth of HuCCT1 (n = 10) and CCLP1 (n = 10) xenografts and representative xenograft tumor images. The tumor growth curves are plotted as mean ± SD (n = 10, each group). All line graphs and bar graphs are presented as mean ± SD of three independent experiments performed in triplicate except otherwise stated. n.s. represents no statistical significance

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