Fig. 5: Analysis of PDK2 effects on tumor growth and glucose metabolism. | Cell Death & Disease

Fig. 5: Analysis of PDK2 effects on tumor growth and glucose metabolism.

From: MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer

Fig. 5

a DNA synthesis in GC cells was measured by Edu incorporation assay. Red fluorescence indicates Edu-positive cells; blue fluorescence from the Hoechst stain represents total cells. b The in vivo effect of PDK2 was evaluated in xenograft mouse models bearing tumors originating from SGC7901 and MGC803 cells; n = 6 per group. c Bioluminescent images of mice administered with SGC7901 and MGC803 cells via the lateral tail veins. Images were taken after 28 days. n = 6 per group. d Bioluminescent images of the metastatic tumors in mice 28 days after intraperitoneal injection with GC cells. n = 6 per group. e Analysis of PDK2 effects on glucose metabolism. The error bars represent the mean (n = 3) ± S.D. *P < 0.05, **P < 0.01, ***P < 0.001 versus corresponding NC

Back to article page