Fig. 1: Identification of miR-29b/142-5p overexpression and DNMTs downregulation in biliary atresia.
From: MicroRNA-29b/142-5p contribute to the pathogenesis of biliary atresia by regulating the IFN-γ gene
a Twenty-seven differentially expressed miRNAs were both upregulated in liver and peripheral blood samples obtained from biliary atresia cases (p < 0.05 with fold-change > 1.5) by miRNAs microarray; b Levels of miR-29b/142-5p in 60 biliary atresia and 16 choledochal cysts liver samples were detected using qPCR and normalized to U6 levels. Levels of DNMTs were detected by qPCR (normalized to β-actin) and western blotting. c The expression levels of miR-142-5p and DNMT1, and miR-29 and DNMT3a/DNMT3b mRNA were significantly negatively correlated (p < 0.001, r = −0.45, −0.71, −0.64, respectively). **p < 0.01, ***p < 0.001. Date represent mean values ± SD
