Fig. 5: HMGB1 is highly expressed in tumor tissues and its expression correlates with worse clinical prognosis. | Cell Death & Disease

Fig. 5: HMGB1 is highly expressed in tumor tissues and its expression correlates with worse clinical prognosis.

From: HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect

Fig. 5

a Box plots summarize the RNA expression levels of HMGB1 across 17 different cancer types. b The expression of HMGB1 in normal and tumor tissue (cervical carcinoma and colorectal carcinoma) from Oncomine database. c The survival analysis of patients with cervical carcinoma from GEPIA database. Upper panel, the overall survival of patients with cervical carcinoma. Lower panel, the disease free survival of patients with cervical carcinoma. d Immunohistochemical staining of HMGB1 in colorectal cancer and adjacent normal tissue. Scale bar: 200 μm (100 μm in the enlarged view). e The score of HMGB1 staining in colorectal cancer tissue and adjacent normal tissue. f The Kaplan–Meier survival analysis in 73 cases of patients with colorectal cancer. g HMGB1 ELISA analysis of patient’s serum pre- and post-treatment. h Schematic depicting the role of HMGB1 released from necrotic cells in promoting tumor proliferation through binding to RAGE and subsequently activate ERK and p38 signaling in surviving cells. *p <0.05; **p <0.01

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