Fig. 6: Bisulphite sequencing reveals increased methylation around the miR-142 genomic locus in the Kras p53R172H cell line. | Cell Death & Disease

Fig. 6: Bisulphite sequencing reveals increased methylation around the miR-142 genomic locus in the Kras p53R172H cell line.

From: MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus

Fig. 6

a 378 bp fragment of a CpG island which contains 18 CpGs and overlaps the miR-142 genomic locus was amplified and investigated using bisulphite sequencing. A schematic shows the location of the CpG island. The lollipop plot shows the location of the CpGs with black spots representing methylated CpGs and white spots representing non-methylated CpGs (a). A two-tailed Mann–Whitney U-test was used to assess for statistically significant differences between the two bisulphite sequencing groups

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