Fig. 1: Follicular quantification by genotype and treatment group.
From: Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility
Total (a), primordial (b), primary (c), secondary (d), and antral follicles (e) were counted in WT, Puma−/− and TAp63−/− female mice treated with saline, cyclophosphamide or cisplatin. Primordial follicles were counted in Puma+/- and TAp63+/- heterozygote mice and compared with WT controls (f). Data are expressed as mean follicles per animal + SEM; *p ≤ 0.05, **p ≤ 0.01, ****p ≤ 0.0001 compared with genotype-matched saline control mice (one-way ANOVA, Tukey’s multiple comparisons test). For clarity, only selected comparisons are shown
