Fig. 3: Fertility studies.
From: Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility
WT, Puma−/− and TAp63−/− mice were treated with saline, cyclophosphamide or cisplatin and then mated continuously with untreated WT males of proven fertility. Time to first litter (a), age at last litter (b), total number of pups per female (c), total number of litters per female (d) and number of pups per litter (e) were assessed. Mean weight at weaning (f) and at 33 days (g) were evaluated in offspring as an overall indicator of gross health. ND not determined. Data are expressed as mean + SEM; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 (one-way ANOVA, Tukey’s multiple comparisons test).
