Fig. 4: Pathways to oocyte apoptosis following DNA damage induced by cyclophosphamide and cisplatin.
From: Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility
DNA damage caused by cisplatin activates a signaling pathway in which TAp63 plays a key regulatory role, with downstream transcriptional induction of Puma, resulting ultimately in the unleashing of the apoptosis effectors BAX and BAK. Cyclophosphamide-induced DNA damage activates an alternate signaling pathway that does not require TAp63; possible mediators are FOXO3a and/or p53. Solid arrows denote known pathways. Dashed arrows denote possible alternative pathways (not yet characterized)
