Table.3 The effects of SIPS on interleukins of CTX-injected mice with hematopoietic dysfunction

From: Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway

  

CTRL

CTX (100 mg/kg)

SIPS (50 mg/kg)

   

--

rhG-CSF (22.5 μg/kg)

SIPS (25 mg/kg)

SIPS (50 mg/kg)

SIPS (100 mg/kg)

 

Serum

IL-1Ra

57.1±4.9

62.9±6.6#

49.1±4.5*

49.6±6.5*

55.6±4.2

42.3±4.1**

48.4±6.1#

IL-2

2515.4±283.0

1964.5±174.1#

1708.9±122.4

2170.9±193.1

2309.3±103.8*

2320.9±304.6*

2166.5±249.8

IL-3

45.0±3.7

38.8±2.1##

61.2±6.6***

45.4±4.3**

54.0±7.4***

59.0±7.1***

43.0±6.3

IL-4

75.8±8.3

66.8±7.5#

93.2±11.4***

77.2±8.0*

85.3±6.8**

83.9±13.0**

73.8±10.2

IL-5

21.2±2.2

12.1±2.4###

19.4±2.9**

17.7±1.4*

19.7±1.8**

15.1±2.7

22.8±3.3

IL-6

74.7±9.6

59.3±5.6#

48.2±5.5*

67.4±2.2*

70.9±9.0*

68.1±4.8*

67.5±4.6

Spleen

IL-1Ra

27.7±4.1

36.1±4.6#

32.6±4.8

33.8±5.1

32.6±3.9

27.9±4.4*

29.9±5.4

IL-2

923.9±44.4

855.1±63.3#

1054.9±128.4**

1023.2±60.1*

1055.6±106.4**

1021.6±76.3*

877.9±52.2

IL-3

21.3±2.1

17.9±0.5#

16.2±1.8

17.4±2.3

18.5±1.6

18.4±2.0

22.1±2.3

IL-4

37.4±4.1

30.2±5.3#

38.6±4.4

38.2±3.1

36.6±2.7

40.9±3.1*

38.5±6.1

IL-5

6.0±1.0

3.4±1.2##

6.0±0.8**

5.6±0.6**

5.7±1.2*

4.9±0.5*

5.2±0.4

IL-6

62.7±4.6

52.4±6.6#

60.6±3.1

69.9±7.6*

58.5±1.4

61.1±4.5

63.8±4.4

  1. Data are expressed as mean ± S.D. (n = 10/group) and analyzed using a one-way analysis of variance followed by Dunn’s test
  2. CTX cyclophosphamide, rhG-CSF recombinant human granulocyte colony-stimulating factor, SIPS Sarcodon imbricatus polysaccharides
  3. #P < 0.05, ##P < 0.01 and ###P < 0.001 vs. control group, *P < 0.05, **P < 0.01 and ***P < 0.001 vs. model group
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