Fig. 6: Schematic representation of the mechanisms underlying apoptosis induced by vorinostat in combination with QC. | Cell Death & Disease

Fig. 6: Schematic representation of the mechanisms underlying apoptosis induced by vorinostat in combination with QC.

From: Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition

Fig. 6

The treatment with vorinostat in combination with QC induced an increase in the level of intracellular ROS, further promoting mitochondrial dysfunction and the accumulation of K63-linked ubiquitination of the mitochondria, which indicates mitophagy. QC blocked autophagy flow through lysosomal dysfunction, resulting in the accumulation of mito-aggresomes and eventually inducing T-ALL cell death

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