Fig. 3: ER stress-induced inflammasome activation does not depend on RIP3. | Cell Death & Disease

Fig. 3: ER stress-induced inflammasome activation does not depend on RIP3.

From: The kinase receptor-interacting protein 1 is required for inflammasome activation induced by endoplasmic reticulum stress

Fig. 3

a, b Secretion of IL-1β and TNF-α by WT, RIP3+/−, and RIP3−/− BMDMs stimulated with LPS plus TG or LPS plus Nigericin. UT unstimulated. c Immunoblot analysis of cleaved caspase-1 (p20) in cell supernatants (SN) and caspase-1 (pro-casp1) and β-actin in cell lysates (Input) of WT, RIP3+/−, and RIP3−/− BMDMs stimulated with LPS plus TG or LPS plus Nigericin. Figures are representative of at least three independent experiments. Bars indicate means plus SD. ns not significant (unpaired Student’s t test)

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