Fig. 6: Cell death is not involved in ER stress-induced inflammasome activation. | Cell Death & Disease

Fig. 6: Cell death is not involved in ER stress-induced inflammasome activation.

From: The kinase receptor-interacting protein 1 is required for inflammasome activation induced by endoplasmic reticulum stress

Fig. 6

a, c Cell death induced by ER stress inducer TG in BMDMs transfected with control siRNA (Scr) or RIP1-specific siRNAs (siRip1) or DRP1-specific siRNAs (siDRP1). The cell death rate was measured by LDH release assay. b Cell death induced by LPS plus TG treatment or LPS plus Nigericin treatment in WT, RIP3+/−, and RIP3−/− BMDMs. d Cell death induced by LPS plus TG with or without pretreatment of various inhibitors as indicated. Results are from three independent experiments with biological duplicates in each. Bars indicate means plus SD. ns not significant (unpaired Student’s t test)

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