Fig. 6: Drosha ameliorated 6-OHDA-induced motor deficits in PD mice
From: Loss of Drosha underlies dopaminergic neuron toxicity in models of Parkinson’s disease
a Experiments design of behavior tests. b–d Open-field parameters: trajectory chart, distance traveled (cm) and mean speed (cm/s). As described in methods, animals were trained before any treatment. The mice were recorded for 10 min in open-field chamber. (ANOVA test followed by Tukey HSD, *P < 0.05, **P < 0.01, n = 12). e, f The time to turn and total time of pole test. (ANOVA test followed by Tukey HSD, *P < 0.05, **P < 0.01, compared with the vehicle control group. #P < 0.05, ##P < 0.01 vs. control vector treated with 6-OHDA. $P < 0.05 vs. WT vector treated with 6-OHDA, n = 12)
