Fig. 7: RA-V inhibits tumor growth and the expression of NF-κB target genes in a nude xenograft model.
From: Natural cyclopeptide RA-V inhibits the NF-κB signaling pathway by targeting TAK1
a–d Inhibition of the growth of HCT116 and HepG2 xenograft tumors by RA-V. Female athymic nude BALB/c mice bearing HCT116 (n = 8) or HepG2 (n = 7) xenograft tumors were intravenously injected with various concentrations of RA-V micelles or control micelles every other day. 5-FU (10 mg/kg) group as positive control. Effects of RA-V on the growth curves of subcutaneoue xenografts of HCT116 (a) and HepG2 (b) and effects on the tumor weight in the HCT116 (c) and HepG2 (d) models. e–f Tumors removed were photographed. g–h The expression of the NF-κB target genes, IL-8, MCP-1, and CXCL-1, in HCT116 (g) and HepG2 (h) tumor tissue from vehicle- and various concentrations of RA-V-treated group was determined by quantitative RT-PCR and normalized to GADPH expression. *, p < 0.05; **, p < 0.01; ***, p < 0.001
