Fig. 1: Early-progressed benign prostatic hyperplasia (BPH) is a stromal component-dominant lesion with excessive collagen deposition. | Cell Death & Disease

Fig. 1: Early-progressed benign prostatic hyperplasia (BPH) is a stromal component-dominant lesion with excessive collagen deposition.

From: M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia

Fig. 1

a Representative haematoxylin and eosin (H&E), immunohistochemical and Masson’s trichrome- staining images showing α-SMA and collagen I expression in the early-progressed BPH, age-matched prostate and elderly BPH tissues. Masson’s trichrome-staining images show the smooth muscle cell cytoplasm in red and the extracellular collagen fibre in blue. Scale bar, 200 μm. b Representative immunofluorescence staining results showing α-SMA (red) and collagen I (green) expression. Scale bar, 100 μm. c Scatter plots showing the stroma-to-epithelium ratios, and the percent area densities of α-SMA, collagen I and collagen fibres in three analysed groups. *P < 0.05, **P < 0.01 and ***P < 0.001. d Heat map showing the distribution of and the relationship between the stroma-to-epithelium ratio, percent area densities of α-SMA, collagen I and fibres and CD68+ cell clusters in the three analysed groups

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