Fig. 2: Upregulation of miR-214 in different liver injury models. | Cell Death & Disease

Fig. 2: Upregulation of miR-214 in different liver injury models.

From: MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression

Fig. 2

a Liver fibrosis was induced by CCl4 injection for 2, 4, 6, or 8 weeks in rats (n = 6 per group). Representative images of H&E-stained and Masson’s trichrome-stained of rat liver sections at ×100 magnification. b The mRNA level of α-SMA and COL1α1 and c miR-214 level was detected in CCl4-treated rat liver sections at different time points. d ORO-stained and H&E-stained images of HFD-treated mouse and control mouse liver at ×100 magnification (n = 3 per group). e miR-214 level was evaluated in liver samples from HFD-fed mice compared to control mice. f miR-214 expression in the liver of cirrhosis or healthy controls was measured by RT-qPCR. Relative expression levels are shown as the means ± standard deviation obtained from triplicate experiments (unpaired two-sample Student’s t test, *P < 0.05 and **P < 0.01)

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