Fig. 5: miR-129/IGF-1 axis regulates proliferation of SCs. | Cell Death & Disease

Fig. 5: miR-129/IGF-1 axis regulates proliferation of SCs.

From: miR-129 controls axonal regeneration via regulating insulin-like growth factor-1 in peripheral nerve injury

Fig. 5

a IGF-1 promoted proliferation of SCs by IGF-1 treatment. b Knocking down of IGF-1 by siRNA (si IGF-1) reduced this effect. c The proliferation rate of SCs transfected with miR-129 was significantly decreased while the proliferation rate of SCs transfected with miR-129 inhibitor was significantly increased compared with that of control (d), but was then rescued by co-transfection with miR-129 inhibitor plus IGF-1 siRNA (anti-miR-129+ si IGF-1). **p < 0.01 versus respective controls. NC (mimic control), anti-NC (inhibitor control)

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