Fig. 8 | Cell Death & Disease

Fig. 8

From: miR-129 controls axonal regeneration via regulating insulin-like growth factor-1 in peripheral nerve injury

Fig. 8

Effects of miR-129/IGF-1/IGF-1R pathway on neurite outgrowth in DRG neurons and SCs in vivo model. a Immunostaining with anti-NF200 or anti-S100β showing that both IGF-1 and miR-129 inhibitor promoted axon outgrowth or SCs migration at 10 days after nerve injury, respectively. The length of regenerative axons from the proximal and SCs migration from the distal nerve stump were measured. PBS (PBS vehicle only), IGF-1 (IGF-1 protein, 100 μg/ml), anti-NC (inhibitor control), anti-miR-129 (miR-129 inhibitor). Scale bar: 500 μm. Also shown are the higher magnifications of boxed areas, in which scale bar: 50 μm. b Histograms showing quantitative comparisons of the length of regenerative axons and SCs migration at 10 days after implantation as the above mentioned. **p < 0.01 versus respective controls. c Schematic diagram showing that miR-129/IGF-1/IGF-1R regulated regenerative microenvironment in the injured sites of sciatic nerve and DRG tissues following PNI

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