Table 2 Univariate quantitative analysis of metabolites commonly detected by all platforms

From: Consequences of blunting the mevalonate pathway in cancer identified by a pluri-omics approach

 

GCMS

LCMS

NMR

Fold change

t-test

Fold change

t-test

Fold change

t-test

Creatine

2.05

0.0015

2.50

0.0476

2.17

0.0003

Fumarate

2.56

0.0143

2.34

0.0000

1.53

0.0114

Glutamate

1.72

0.0013

1.98

0.0000

1.53

0.0096

Glutamine

6.52

0.0009

7.12

0.0000

6.60

0.0129

Lactic acid

3.08

0.0038

3.96

0.0058

4.30

0.0275

Myo-inositol

2.56

0.0011

1.61

0.0220

1.68

0.0034

  1. HGT-1 cancer cells were treated for 36 h and collected for biochemical analyses. The identified metabolites are listed in alphabetical order. The fold-changes and the p-values (Student t-test, p < 0.05) are shown
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