Fig. 2: Analyses of mtDNA content, gene expression, and OXPHOS activity in mtDNA-depleter mice
From: Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function
a Quantification of mtDNA content (mean ± s.e.m; *P<0.05, Student’s t test) in skin samples from wild-type control (WT; n = 3) and mtDNA-depleter (Depleter; n = 3) mice after 2 months of continuous dox induction. b–d RT-PCR analysis of mtDNA-encoded genes (b), Western blot analysis of OXPHOS subunits (c), and BN-PAGE analysis of OXPHOS supercomplexes (d) in the skin of wild-type control and mtDNA-depleter mice after 2 months of continuous dox induction. e–i Enzymatic activities of OXPHOS complex I (e), II (f), III (g), IV (h), and V (i) in the skin of wild-type control and mtDNA-depleter mice after 2 months of continuous dox induction. Depleter = mtDNA-depleter mice
