Fig. 1: Experimental strategy and RISC-associated miRNAs and mRNAs. | Cell Death & Disease

Fig. 1: Experimental strategy and RISC-associated miRNAs and mRNAs.

From: High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2

Fig. 1

a Experimental plan outline. b, c Volcano plot of differentially modulated miRNAs and mRNAs, revealed by RISC-associated RNA-sequencing. miRNAs (b) and mRNAs (c), differentially modulated in RISC complex of DM1 patients compared to CTRs. Red dots represent miRNAs and mRNAs displaying statistically significant differences (FDR < 0.1; DM1, n = 3; CTR, n = 3). miRNAs with mRNA targets differentially modulated in the RISC, and validated mRNAs are identified by name in b and c, respectively

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