Fig. 5: Docking of muricins in the transmembrane domain of Na+ and K+-ATPase (PDB ID: 4HYT) with GOLD 5.2. | Cell Death & Disease

Fig. 5: Docking of muricins in the transmembrane domain of Na+ and K+-ATPase (PDB ID: 4HYT) with GOLD 5.2.

From: RETRACTED ARTICLE: Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways

Fig. 5

a Docking validation showing an overlay of co-crystallized (green) and docked ouabain (light blue). b Annonacin. c Overlay of the docked compounds. d Modulation of the ATPase activity of the Na+and K+-ATPase in vitro with extracts from Annona muricata. e Comparison of ER Ca2+ refilling kinetics under control conditions and in the presence of 1 mh/ml Graviola extract (n = 5). g Estimation of SERCA pump activity by measuring ER Ca2+ refilling of previously emptied ER (n = 3–6). f NKA pump inhibition curve showing the effect of Graviola (red) and amygdalin (black)

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