Fig. 6: NKA and SERCA pumb subunit-related survival analysis of different cancer types; Bio-Profile study. | Cell Death & Disease

Fig. 6: NKA and SERCA pumb subunit-related survival analysis of different cancer types; Bio-Profile study.

From: RETRACTED ARTICLE: Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways

Fig. 6

a (I-II, breast cancer; III colon cancer; IV kidney cancer) Survival analysis of NKA genes expression. b (I, adenocortical carcinoma; II, brain cancer; III breast cancer) Survival analysis of SERCA genes expression. c Effect of Graviola extract in MIA PaCa-2 xenografts. MIA PaCa2 at an inoculation density of 1 × 106 cells/injection was injected subcutaneously into the axillary region of female NOD/SCID mice (age 8–10 weeks). When tumors reached ~200 mm, three animals were randomized into three groups (untreated, carrier, and Graviola treated), where each one consisted of eight mice and administrations were started. Graviola extract was administered at a dose of 25 mg/kg in a 5% Cremophore ELP/10% DMSO/NS and a 5 days on/2 days off schedule (arrows show administrations, where numbers above the arrows show the days post tumor cell’s inoculation). Each point shows the mean ± SD. The experiment ended when tumors of the untreated mice reached a volume of about 2000 mm3 (~10% of mice’s weight)

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