Table 2 Correlation of PIK3CA mutations with clinicopathological characteristics of CRC patients
From: PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer
Characteristic | Wild type (%) | Mutant (%) | P value |
|---|---|---|---|
Total | 398 | 42 | |
Gender | |||
Male | 242 | 29 | 0.296 |
Female | 156 | 13 | |
ECOG | |||
0 | 359 | 39 | 0.577 |
1, 2 | 39 | 3 | |
Age | |||
≤59 | 198 | 22 | 0.746 |
>59 | 200 | 20 | |
Tumor location | |||
RCC | 76 | 7 | 0.702 |
LCRC | 322 | 35 | |
Histological grade | |||
Low | 80 | 20 | <0.001 |
Medium-High | 318 | 22 | |
LN metastasis | |||
Yes | 152 | 13 | 0.357 |
No | 246 | 29 | |
TNM stage | |||
I–II | 220 | 17 | 0.034 |
III–IV | 178 | 25 | |
