Fig. 5: A graphical summary of the proposed lncTAM34a function.
From: An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a
Stress stimuli, originating in the cytoplasm or nucleus, activate TP53 as well as additional factors. These factors then bind to the miR34a promoter and drive baseline transcription levels of the sense and antisense strands. lncTAM34a serves to further increase miR34a HG transcription levels resulting in enrichment of polymerase II at the miR34a promoter and a positive feed-forward loop. miR34a HG then, in turn, is spliced and processed in multiple steps before the mature miR34a binds to the RISC complex allowing it to repress its targets and exert its tumor suppressive effects
