Fig. 3: Activated Wnt/β-catenin signaling regulates M2 macrophage polarization through c-Myc. | Cell Death & Disease

Fig. 3: Activated Wnt/β-catenin signaling regulates M2 macrophage polarization through c-Myc.

From: Crosstalk between hepatic tumor cells and macrophages via Wnt/β-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors

Fig. 3

a BMDMs were transfected with c-Myc siRNA (sic-Myc) or randomized siRNA control (siR) for 24 h, and then the cells were stimulated with IL-4 for 24 h. The expression of M2 markers was determined by qRT-PCR, and compared quantitatively among each group (n = 3). b BMDMs were transfected with sic-Myc or siR for 24 h, and then the cells were polarized with IL-4 in the presence of Wnt3a for 24 h. The expression of M2 markers was determined by qRT-PCR, and compared quantitatively among each group (n = 3). Bars, mean ± SD; *P < 0.05; **P < 0.01; ***P < 0.001

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