Fig. 2: BAP31 expression is increased in cervical cancer patients and positively correlated with survival. | Cell Death & Disease

Fig. 2: BAP31 expression is increased in cervical cancer patients and positively correlated with survival.

From: BAP31, a newly defined cancer/testis antigen, regulates proliferation, migration, and invasion to promote cervical cancer progression

Fig. 2

a BAP31 mRNA levels from paired cervical tumors and adjacent normal tissues were analyzed by real-time PCR. *p < 0.05 was considered significant for the cervical tumor vs adjacent normal tissues. b The expression of BAP31 in five paired cervical tumors and adjacent normal tissues was determined by western blotting. c Paraffin sections of normal cervical and cervical cancer tissues were subjected to H&E staining and immunohistochemical staining using BAP31 antibody. The scale bars represent 1 mm and 100 μm. d, e Immunohistochemistry analysis of BAP31 staining score in 26 normal cervical tissue and 161 cervical cancer tissues. p value was calculated by one-way ANOVA. *p < 0.05, **p < 0.01, and ***p < 0.001. f Correlation between tissue BAP31 level and Ki-67 staining score was tested by Spearman’s rank correlation analysis, with r and p values indicated. g Kaplan–Meier survival curve showing overall survival of cervical cancer patients with low (n = 53) or high (n = 54) levels of BAP31 expression. Patients’ survival data were derived from 107 cervical cancer patients, and 54 patients were loss to follow-up. h Kaplan–Meier survival curves of breast cancer, gastric cancer, and lung cancer with low and high BAP31 expression from the Kaplan–Meier Plotter database. (p < 0.01 by log-rank test)

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