Fig. 1: ZDHHC8 upregulation in the brain tissues of epileptic patients and mice.
From: ZDHHC8 critically regulates seizure susceptibility in epilepsy
a, b ZDHHC8 levels were increased in temporal lobe samples from TLE patients compared with those in the controls. Western blot showing ZDHHC8 levels (n = 16 per group, ***P < 0.001 compared to the controls, unpaired t-test). c, d ZDHHC8 levels were increased in the cortical (c) and hippocampal (d) lysates of epileptic mice compared with those in the controls (non-epileptic mice) (n = 6 per group, **P < 0.01, unpaired t-test). e, f ZDHHC8 (green) and MAP-2 (blue), but not GFAP (red), co-localized (merged) in the cortex of the temporal lobe samples from the controls, patients with TLE (a–d), and epileptic mice (e–h) as well as in the hippocampus of the controls and epileptic mice (i–l). Arrows indicate positive cells. High-magnification photomicrographs corresponding to specific cells are shown at the bottom. g Quantification of ZDHHC8-positive cells co-localized with MAP-2 in the epileptic and control brains in human and mice (n = 8)
