Fig. 5: The ciRS-7/miR-7 promotes proliferation and migration of ESCC cells via HOXB13. | Cell Death & Disease

Fig. 5: The ciRS-7/miR-7 promotes proliferation and migration of ESCC cells via HOXB13.

From: CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13

Fig. 5

a Colony formation assays of Eca109 cells after overexpression of ciRS-7, miR-7, HOXB13, or siRNA transfection. Left panel was representative images and right panel was statistical quantification. b Migration assays of Eca109 cells after overexpression of ciRS-7, miR-7, HOXB13, or siRNA transfection. Left panel was representative images and right panel was statistical quantification. c Western blot analysis of phosphor-p65 after ciRS-7 or miR-7 overexpression or siRNA transfection. d Correlation between expression level of ciRS-7 and miR-7 in ESCC tumor tissues. e Overall survival of ESCC patients based on expression level of ciRS-7 and miR-7 (low risk, low ciRS-7, and high miR-7; intermediate risk, low ciRS-7 and low miR-7, or high ciRS-7 and high miR-7; high risk, high ciRS-,7 and low ciRS-7). Data in a and b represents the mean ± SD of three repeated experiments. *P < 0.05

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