Fig. 6: Knockdown of spinal Fbxo45 expression reverses the SNL-enhanced frequency and amplitude of mEPSCs in the ipsilateral dorsal horn. | Cell Death & Disease

Fig. 6: Knockdown of spinal Fbxo45 expression reverses the SNL-enhanced frequency and amplitude of mEPSCs in the ipsilateral dorsal horn.

From: Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats

Fig. 6

a Representative traces and statistical analysis of miniature EPSCs (mEPSCs) recorded in the ipsilateral dorsal horn of spinal slices showing that when compared with naive animals (naive), the inter-event interval of mEPSCs was significantly shorter and the amplitude was larger in animals receiving Fbxo45 siRNA but not missense siRNA (Fbxo45 siRNA and MS siRNA, respectively; 3 μg, 10 μL; once daily for 4 days; Kolmogorov–Smirnov test). **P < 0.01 compared with naive (n = 3–4). Results were expressed as mean ± SEM

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