Fig. 7: Co-expression of SOX9 and COL10A1 correlates with a poor prognosis in human GC. | Cell Death & Disease

Fig. 7: Co-expression of SOX9 and COL10A1 correlates with a poor prognosis in human GC.

From: TGF-β1-SOX9 axis-inducible COL10A1 promotes invasion and metastasis in gastric cancer via epithelial-to-mesenchymal transition

Fig. 7

a IHC staining of SOX9 and COL10A1 was performed in the TMA containing 99 gastric cancer patients. b SOX9 and COL10A1 protein expression levels in normal and GC tissues. ***P < 0.001 between normal and GC tissues. c The protein expression levels of SOX9 and COL10A1 were semi-quantified, and the correlation between these two proteins was evaluated with Spearman’s rank correlation method. ***P < 0.001. d IHC staining of SOX9 and COL10A1 expression in human GC (AJCC stages I–IV). e Overall survival of GC patients was analyzed using the Kaplan-Meier method. Survival analysis was performed according to the expression of SOX9 and COL10A1. Co-expression of SOX9 and COL10A1 was associated with a poor prognosis in GC patients. f A hypothetical model demonstrating that the TGF-β1-SOX9 axis contributes to the transcriptional activation of COL10A1 and promotes GC aggressiveness. Scale bars represent 100 μm in (a, d)

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