Fig. 1 | Cell Death & Disease

Fig. 1

From: The antiproliferative and apoptotic profile of gomesin against DFTD

Fig. 1

Diagram showing the antiproliferative and apoptotic profile of gomesin-spider peptides in DFTD cells. Gomesin peptides cause cellular stress owing to an increase in the cellular reactive oxygen species (ROS), a reduction of the mitochondrial membrane potential (MMP) and stimulation of the expression of p53, p21, p27, BCL2 and MLC1. The model postulates that all together lead to cellular necrosis and subsequent reduced DFTD cell viability. Gomesin cytotoxicity is prevented by alanine substitution in residues R3, L5 or V12. The model also suggests that gomesin may assist in the development of a drug candidate against DFTD and thus to a DFTD-free Tasmanian devil population

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