Fig. 5: Regulation of hepatic COX2/prostaglandin metabolism by BBR. | Cell Death & Disease

Fig. 5: Regulation of hepatic COX2/prostaglandin metabolism by BBR.

From: Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis

Fig. 5

a KEGG analysis of the top 10 pathways in the livers of mice fed with atherogenic diet (AD) alone or with berberine (AD + BBR). b Expression of key genes involved in the hepatic metabolism of arachidonic acid and prostaglandin metabolites. c Changes of the COX2 protein levels in the livers of mice fed with different diets. *p < 0.05 compared with chow diet. #p < 0.05 compared with AD. d Heatmap show of arachidonic acid and prostaglandin metabolites in the livers of mice fed with chow, AD, and AD + BBR. e Levels of arachidonic acid and prostaglandin metabolites among groups (unit: ng/mg liver). *p < 0.05 and **p < 0.01 compared with chow diet. #p < 0.05 and ##p < 0.01 compared with AD

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